CLINICAL TRIALS
Dr. Aplenc is the Primary Investigator on anti-CD123/CD38 CAR trials at the Children's Hospital of Philadelphia and the co-inventor for a CD38 CAR currently in clinical trials. In addition, he led the recently completed Phase III trial (AAML1031) for children with AML in the Children's Oncology Group (COG) and served as the Vice-Chair of the COG Strategy AML Committee
Glisovic-Aplenc T, Diorio C, Chukinas JA, Veliz K, Shestova O, Shen F, Nunez-Cruz S, Vincent TL,Miao F, Milone MC, June CH, Teachey DT, Tasian SK, Aplenc R, Gill S. CD38 as a pan-hematologictarget for chimeric antigen receptor T cells. Blood Adv. 2023 Aug 22;7(16):4418-4430. PubMed CentralPMCID: PMC10440474.
Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR,DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL,Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, LevineBL, June CH, Grupp SA, Maude SL. Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) TCells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory AcuteLymphoblastic Leukemia. J Clin Oncol. 2021 Sep 20;39(27):3044-3055. PubMed Central PMCID:PMC9851702.
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Aplenc R, Meshinchi S, Sung L, Alonzo T, Choi J, Fisher B, Gerbing R, Hirsch B, Horton T, Kahwash
S, Levine J, Loken M, Brodersen L, Pollard J, Raimondi S, Kolb EA, Gamis A. Bortezomib with
standard chemotherapy for children with acute myeloid leukemia does not improve treatment
outcomes: a report from the Children's Oncology Group. Haematologica. 2020 Jul;105(7):1879-1886.
PubMed Central PMCID: PMC7327649.
Getz KD, Sung L, Alonzo TA, Leger KJ, Gerbing RB, Pollard JA, Cooper T, Kolb EA, Gamis AS, Ky B,
Aplenc R. Effect of Dexrazoxane on Left Ventricular Systolic Function and Treatment Outcomes in
Patients With Acute Myeloid Leukemia: A Report From the Children's Oncology Group. J Clin Oncol. 2020 Jul 20;38(21):2398-2406. PubMed Central PMCID: PMC7367546.
Getz KD, Sung L, Ky B, Gerbing RB, Leger KJ, Leahy AB, Sack L, Woods WG, Alonzo T, Gamis A,
Aplenc R. Occurrence of Treatment-Related Cardiotoxicity and Its Impact on Outcomes Among
Children Treated in the AAML0531 Clinical Trial: A Report From the Children's Oncology Group. J Clin Oncol. 2019 Jan 1;37(1):12-21. PubMed Central PMCID: PMC6354770.
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